Put Zen Back into the Analysis of Biologics

Introducing bioZen biocompatible UHPLC/HPLC columns, a growing collection of innovative and acclaimed UHPLC/HPLC and SEC column phases created and tested to make bio-separation scientists lives a little more Zen for:

Aggregate Analysis
Drug Antibody Ratio (DAR)
Glycan Analysis
Intact Mass

Intact and Fragment Analysis
Peptide Mapping
Peptide Quantitation
Charge Variant Analysis(IEX)

bioZen Thermally modified fully porous particle for biomolecules

bioZen Core-shell Technology Particle for biomolecules

bioZen Monosized Polymeric Non-Porous Particle for biomolecules

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<h2 class="bio-intro">Put Zen Back into the Analysis of Biologics</h2>

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<p>Introducing <span class="blue-bold">bio</span><span class="green-bold">Zen</span> <strong>biocompatible UHPLC/HPLC columns</strong>, a growing collection of innovative and acclaimed UHPLC/HPLC and SEC column phases created and tested to make bio-separation scientists lives a little more Zen for:</p>

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<ul class="biotop-analysis-benefits">
	<li>Aggregate Analysis</li>
	<li>Drug Antibody Ratio (DAR)</li>
	<li>Glycan Analysis</li>
	<li>Intact Mass</li>
</ul>

<ul class="biotop-analysis-benefits">
	<li>Intact and Fragment Analysis</li>
	<li>Peptide Mapping</li>
	<li>Peptide Quantitation</li>
	<li>Charge Variant Analysis(IEX)</li>
</ul>
</div>

<div class="btn-group" id="microsite-button" style="display:none"><a class="btn btn-primary dropdown-toggle" data-toggle="dropdown" href="#">Enter the Biozen Microsite</a> <a class="btn btn-primary dropdown-toggle" data-toggle="dropdown" href="#"> <img src="/webimage/white-triangle-drawing.png" style="display:inline-block" width="12" /></a>

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	<li><a href="http://biologic.azurewebsites.net/" target="_blank">English</a></li>
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Applications
All Applications »

Featured

BROCHURE

bioZen brochure

RP, HILIC, IEX, and SEC solutions for the analysis of biologics such as mAbs and ADCs.
TECHNICAL NOTE

Aggregate Analysis Technote

Learn how bioZen SEC columns are able to detect monoclonal antibody aggregates and fragments
TECHNICAL NOTE

Charge Variant Analysis Technote

See how our new bioZen 6 µm WCX column is capable of detecting both acidic and basic variants under salt and pH gradient conditions.
APPLICATION

Released N-Glycan Labeling Clean-Up

This application note compares two glycan clean-up solutions for a commercially available in-solution digestion and labeling kit for glycan profiling of a trastuzumab biosimilar and a heavily sialylated glycoprotein.

Featured Biologics Analysis

2-AB Labeled Glycans from Standard Solution

Excellent Separation and Selectivity!

Flow Rate:0.5 mL/min
Peptide Map Cetuximab

Utilize complementary bioZen selectivities
for easier characterization of PTMs.

Flow Rate:0.6 mL/min
Aggregate Analysis Herceptin - mcMMAF

Excellent ADC Peak Shape!

Flow Rate:0.2 mL/min
Intact Analysis Trastuzumab at 70, 80, and 90 °C

Useful temperature stability up to 90 °C!.

Flow Rate:0.5 mL/min
Intact Mass of NIST mAb using a bioZen Intact C4 and SCIEX® X500B

Fast run times and tight peak shapes

Flow Rate:0.5 mL/min
Herceptin—vcMMAE using bioZen 3.6 μm Intact XB-C8

Excellent isomer separation!

Flow Rate: 0.3 mL/min

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<h2>Featured Biologics Analysis</h2>

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<ul class="bio-featured-list">
	<li class="app-one">
	<h2>2-AB Labeled Glycans from Standard Solution</h2>

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	<div class="app-caption">Excellent Separation and Selectivity!</div>

<div class="flow-rate-caption">Flow Rate:0.5 mL/min</div>
	<img border="0" src="/webimage/glycan_analysis_appshot.png" width="590" /> </div>
	</li>
	<li class="app-two">
	<h2>Peptide Map Cetuximab</h2>

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	<div class="app-caption">Utilize complementary bioZen selectivities<br />
	for easier characterization of PTMs.</div>

<div class="flow-rate-caption">Flow Rate:0.6 mL/min</div>
	<img src="/webimage/peptide_mapping_biozenindustry_appshot2.png" width="590" /> </div>
	</li>
	<li class="app-three">
	<h2>Aggregate Analysis Herceptin - mcMMAF</h2>

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	<div class="app-caption">Excellent ADC Peak Shape!</div>

<div class="flow-rate-caption" style="right:275px;top:56px;">Flow Rate:0.2 mL/min</div>
	<img src="/webimage/aggregate_biozenindustry_appshot.png" width="590" /> </div>
	</li>
	<li class="app-four" style="display:none">
	<h2>Intact Analysis Trastuzumab at 70, 80, and 90 °C</h2>

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	<div class="app-caption" style="left:40px">Useful temperature stability up to 90 °C!.</div>

<div class="flow-rate-caption" style="right:455px">Flow Rate:0.5 mL/min</div>
	<img src="/webimage/intact_analysis_biozenindustry_appshot.png" width="590" /> </div>
	</li>
	<li class="app-five" style="display:none">
	<h2>Intact Mass of NIST mAb using a bioZen Intact C4 and SCIEX® X500B</h2>

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	<div class="app-caption" style="left:95px">Fast run times and tight peak shapes</div>

<div class="flow-rate-caption" style="right:255px">Flow Rate:0.5 mL/min</div>
	<img src="/webimage/intact_nist_biozenindustry_appshot.png" width="590" /> </div>
	</li>
	<li class="app-six" style="display:none">
	<h2>Herceptin—vcMMAE using bioZen 3.6 μm Intact XB-C8</h2>

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	<div class="app-caption" style="left:95px">Excellent isomer separation!</div>

Applications
All Applications »

Featured Technical Tips

<h2>Featured Technical Tips</h2>

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<a onclick="_ga('send', 'event', 'Technical Note: Size Exclusion and a Well Salted Buffer', 'clicked', 'Technical Library  Biozen Webpage');" target="_blank" href="/Info/WebDocumentServe/tech1_tn58910218_w.pdf"><img src="/webimage/biozen_techtip1a.png"/><p>Size Exclusion and a Well Salted Buffer</p></a>
</li>

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<a onclick="_ga('send', 'event', 'Technical Note: Deglycosylation Topics', 'clicked', 'Technical Library  Biozen Webpage');" target="_blank" href="/Info/WebDocumentServe/tech2_tn58920218_w.pdf"><img src="/webimage/biozen_techtip2.png"/><p>Deglycosylation Topics</p></a>
</li>

<li>
<a onclick="_ga('send', 'event', 'Technical Note: Loading Capacity for SEC and Reversed Phase HPLC/UHPLC', 'clicked', 'Technical Library  Biozen Webpage');" target="_blank" href="/Info/WebDocumentServe/tech3_tn58930218_w.pdf"><img src="/webimage/biozen_techtip3.png"/><p>Loading Capacity for SEC and Reversed Phase HPLC/UHPLC</p></a>
</li>

<li>
<a onclick="_ga('send', 'event', 'Technical Note: Organic Solvent and Size Exclusion', 'clicked', 'Technical Library  Biozen Webpage');" target="_blank" href="/Info/WebDocumentServe/tech4_tn58940218_w.pdf"><img src="/webimage/biozen_techtip4.png"/><p>Organic Solvent and Size Exclusion</p></a>
</li>

<li>
<a onclick="_ga('send', 'event', 'Technical Note: Peptide Mapping', 'clicked', 'Technical Library  Biozen Webpage');" target="_blank" href="/Info/WebDocumentServe/tech5_tn58950218_w.pdf"><img src="/webimage/biozen_techtip5.png"/><p>Peptide Mapping</p></a>
</li>

<li>
<a onclick="_ga('send', 'event', 'Technical Note: Drug-Antibody Ratio (DAR)', 'clicked', 'Technical Library  Biozen Webpage');" target="_blank" href="/Info/WebDocumentServe/tech6_tn58960218_w.pdf"><img src="/webimage/biozen_techtip6.png"/><p> Drug-Antibody Ratio (DAR)</p></a>
</li>

<li>
<a onclick="_ga('send', 'event', 'Technical Note: Intact Mass', 'clicked', 'Technical Library  Biozen Webpage');" target="_blank" href="/Info/WebDocumentServe/tech7_tn59020218_w.pdf"><img src="/webimage/biozen_techtip7.png"/><p> Intact Mass</p></a>
</li>

<li>
<a onclick="_ga('send', 'event', 'Technical Note: N-Glycan Analysis', 'clicked', 'Technical Library  Biozen Webpage');" target="_blank" href="/Info/WebDocumentServe/tech8_tn59410318_w.pdf"><img src="/webimage/biozen_techtip8.png"/><p> N-Glycan Analysis</p></a>
</li>

</ul>

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<h2>Featured Guides</h2>

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<p><a target="_blank" href="/Info/WebDocumentServe/biobrochure_guide.pdf">bioZen Product Guide </p>

</div>

</div>

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<p><a target="_blank" href="/Info/WebDocumentServe/bio_miniguide.pdf">bioZen Column Hardware Guide </p>

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</div>

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Applications

All Applications »

Introducing

bioZen LC Columns

for Biopharmaceutical Analysis

Put Zen Back into the Analysis of Biologics

Featured

Featured Biologics Analysis

2-AB Labeled Glycans from Standard Solution

Peptide Map Cetuximab

Aggregate Analysis Herceptin - mcMMAF

Intact Analysis Trastuzumab at 70, 80, and 90 °C

Intact Mass of NIST mAb using a bioZen Intact C4 and SCIEX® X500B

Herceptin—vcMMAE using bioZen 3.6 μm Intact XB-C8

Featured Technical Tips

Featured Guides